Publications

28. “Development of a Scalable, Chromatography-Free Synthesis of t-Bu-SMS-Phos and Application to the Synthesis of an Important Chiral CF3-Alcohol Derivative in High Enantioselectivity Using Rh-Catalyzed Asymmetric Hydrogenation.”
Sieber, J. D.; Rodriguez, S.; Frutos, R.; Buono, F.; Zhang, Y.; Li, N.; Qu, B.; Premasiri, A.; Li, Z.; Han, Z. H.; Xu, Y.; Byrne, D.; Haddad, N.; Lorenz, J.; Grinberg, N.; Kurouski, D.; Lee, H.; Narayanan, B.; Nummy, L.; Mulder, J.; Brown, J. D.; Granger, A.; Gao, J.; Krawiec, M.; Williams, Z.; Pennino, S.; Song, J. J.; Hossain, A.; Yee, N. K.; Busacca, C.; Roschangar, F.; Xin, Y.; Mao, Z.; Zhang, X.; Hong, Y.; Senanayake, C. H.  J. Org. Chem. 2018, 83, 1448 – 1461.

tBuDIPAMP-JOC-2018
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27. “Enantioselective Synthesis of a-(Hetero)aryl Piperidines throught Asymmetric Hydrogenation of Pyridinium Salts and Its Mechansistic Insights”
Qu, B.; Mangunuru, H. P. R.; Tcyrulnikov, S.; Rivalti, D.; Zatolochnaya, O. V.; Kurouski, D.; Radomkit, S.; Biswas, S.; Karyakarte, S.; Fandrick, D. R.; Sieber, J. D.; Rodriguez, S.; Desrosiers, J. –N.; Haddad, N.; McKellop, K.; Pennino, S.; Lee, H.; Yee, N. K.; Song, J. J.; Kozlowski, M. C.; Senanayake, C. H.  Org. Lett. 2018, 20, 1333 – 1337.

Pyridiniums-OL-2018
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26. “BABIPhos Family of Biaryl Dihydrobenzooxaphosphole Ligands for Asymmetric Hydrogenation.”
Li, G.; Zatolochnaya, V.; Wang, X. –J.; Rodriguez, S.; Qu, B.; Desrosiers, J. –N.; Mangunuru, G. P. R.; Biswas, S.; Rivalti, D.; Karyakarte, S. D.; Sieber, J. D.; Grinberg, N.; Wu, L.; Lee, H.; Haddad, N.; Fandrick, D. R.; Yee, N. K.; Song, J. J.; Senanayake, C. H. Org. Lett. 2018, 20, 1725 – 1729.

BABIPhos-OL-2018
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25. “Copper-Catalyzed Asymmetric Hydrogenation of 2-Substituted Ketones via Dynamic Kinetic Resolution.”
Zatolochnaya, O. V.; Rodriguez, S.; Zhang, Y.; Lao, K. S.; Tcyrulnikov, S; Si, G.; Wang, X. –J.; Qu, B.; Biswas, S.; Mangunuru, H. P. R.; Rivalti, D. R.; Sieber, J. D.; Desrosiers, J. –N.; Leung, J. C.; Grinberg, N.; Lee, H.; Haddad, N.; Yee, N. K.; Song, J. J.; Kozlowski, M. C.; Senanayake, C. H. Chem. Sci 2018, 9, 4505 – 4510.

ChemSci-2018
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24. “Modular Dihydrobenzoazaphosphole Ligands for Suzuki-Miyaura Cross-Coupling.”
Zhang, Y.; Lao, K. S.; Sieber, J. D.; Xu, Y.; Wu, L.; Wang, X. –J.; Desrosiers, J. –N.; Lee, H.; Haddad, N.; Han, Z. S.; Yee, N. K.; Song, J. J.; Howell, A. R.; Senanayake, C. H.  Synthesis 2018, 50, DOI:  10.1055/s-0037-1610158.

Special issue in honor of Prof. Scott Denmark’s 65th birthday

Synthesis-2018
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23. “Effective BI-DIME Ligand for Suzuki-Miyaura Cross-Coupling Reactions in Water with 500 ppm Palladium Loading and Triton X.”
Patel, N. D.; Rivalti, D.; Buono, F. G.; Chatterjee, A.; Qu, B.; Braith, S.; Desrosiers, J. –N.; Rodriguez, S.; Sieber, J. D.; Haddad, N.; Fandrick, K. R.; Lee, H.; Yee, N. K.; Busacca, C. A.; Senanayake, C. H. Asian J. Org. Chem. 2017, 6, 1285 – 1291.

Micelles-AJOC-2017
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22. “Ligand Enabled Pd(II)-Catalyzed Bromination and Iodination of C(sp3)-H Bonds.”
Zhu, R. –Y.; Saint-Denis, Y. G.; Shao, Y.; He, J.; Sieber, J. D.; Senanayake, C. H.; Yu, J. –Q.  J. Am. Chem. Soc. 2017, 139, 5724 – 5727.

JinQuanYu-JACS-2017
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21. “Rhodium-Catalyzed Asymmetric Allenylation of Sulfonylimines and Application to the Stereospecific Allylic Allenylation”
Sieber, J. D.; Angeles-Dunham, V. V.; Chennamadhavuni, D.; Fandrick, D. R.; Haddad, N.; Grinberg, N.; Kurouski, D.; Lee, H.; Song, J. J.; Yee, N. K.; Mattson, A. E.; Senanayake, C. H.   Adv. Synth. & Catal. 2016, 358, 3062 – 3068.

Allenylation-AdvSynthCatal-2016
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20. “Rh-Catalysed Asymmetric Conjugate Addition of Boronic Acids to Nitroalkenes Employing a P-Chiral PHybrid Ligand.”
Sieber, J. D.; Rivalti, D.; Herbage, M. A.; Masters, J. T.; Fandrick, D. R.; Fandrick, D. R.; Haddad, N.; Lee, H.; Yee, N. K.; Gupton, B. F.; Senanayake, C. H.  Org. Chem. Front. 2016, 3, 1149 – 1153.

Special issue in honor of Prof. Barry Trost’s 75th birthday

OrgChemFront-2016
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19. “Synthesis of P-Chiral Dihydrobenzooxaphospholes Through Negishi Cross-Coupling.”
Sieber, J. D.; Qu, B.; Rodriguez, S.; Haddad, N.; Grinberg, N.; Lee, H.; Song, J. J.; Yee, N. K.; Senanayake, C. H.  J. Org. Chem. 2016, 81, 729 – 736.

Negishi-JOC-2016
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18. “Synthesis of Enantioenriched 2-Alkyl Piperidine Derivatives Through Asymmetric Reduction of Pyridinium Salts.”
Qu, B.; Mangunuru, H. P. R.; Wei, X.; Fandrick, K. R.; Desrosiers, J. –N.; Sieber, J. D.; Kurouski, D.; Haddad, N.; Samankumara, L. P.; Lee, H.; Savoie, J.; Ma, S.; Grinberg, N.; Sarvestani, M.; Yee, N. K.; Song, J. J.; Senanayake, C. H. Org. Lett. 2016, 18, 4920 – 4923.

Pyridiniums-OL-2016
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17. “Ligand-Accelerated Stereoretentive Suzuki-Miyaura Coupling of Unprotected 3,3’-Dibromo-BINOL.”
Qu, B.; Haddad, N.; Rodriguez, S.; Sieber, J. D.; Desrosiers, J. –N.; Patel, N. D.; Zhang, Y.; Grinberg, N.; Lee, H.; Ma, S.; Ries, U. J.; Yee, N. K.; Senanayake, C. H.  J. Org. Chem. 2016, 81, 745 – 750.

BINOL-Suzuki-JOC-2016
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16. “Reengineered BI-DIME Ligand Core Based on Computer Modeling to Increase Selectivity in Asymmetric Suzuki-Miyaura Coupling for the Challenging Axially Chiral HIV Integrase Inhibitor.”
Haddad, N.; Mangunuru, H. P. R.; Fandrick, K. R.; Qu, B.; Sieber, J. D.; Rodriguez, S.; Desrosiers, J. –N.; Patel, N. D.; Lee, H.; Kurouski, D.; Grinberg, N.; Yee, N. K.; Song, J. J.; Senanayake, C. H.   Adv. Synth. & Catal. 2016, 358, 3522 – 3527.

NizarPhos
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15. “Rh-Catalyzed Reagent-Free Ring Expansion of Cycobutenones and Benzocyclobutenones.”
Chen, P. -H.; Sieber, J. D.; Senanayake, C. H.; Dong, G.  Chem. Sci. 2015, 6, 5440 – 5445.

Guangbin-ChemSci-2015
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14. “Efficient Asymmetric Synthesis of Structurally Diverse P-Stereogenic Phosphinamides for Catalyst Design.”
Han, Z. S.; Zhang, L.; Xu, Y.; Sieber, J. D.; Marsini, M. A.; Li, Z.; Reeves, J. T. ; Fandrick, K. R. ; Patel, N. D. ; Desrosiers, J. –N. ; Qu, B. ; Chen, A. ; Rudzinski, D. M. ; Samankumara, L. P. ; Ma, S. ; Grinberg, N. ; Roschangar, F. ; Yee, N. K. ; Wang, G. ; Song, J. J. ; Senanayake, C. H.  Angew. Chem. Int. Ed. 2015, 54, 5474 – 5477.

Phosphinamides-ACIE-2015
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13. “Development of a Practical Sequence for Difluoromethylation of 2-Bromopyridines via Copper-Mediated Reductive Coupling and Decarboxylation.”
Zeng, X.; Wei, X.; Song, J. J.; Sarvestani, M.; Fandrick, D. R.; Qu, B.; Rodriguez, S.; Sieber, J. D.; Desrosiers, J. –N.; Yee, N. K.; Roschangar, F.; Senanayake, C. H.  Asian J. Org. Chem. 2015, 4, 1262 – 1264.

John-Zeng-AsianJOC
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12.“Copper-Catalyzed Electrophilic Amination of Heteroaromatic and Aromatic C-H Bonds via TMPZnCl-LiCl Mediated Metalation.”
McDonald, S. L.; Hendrick, C. E.; Bitting, K. J.; Wang, Q.; Sieber, J. D.; Senanayake, C. H.  Org. Synth. 2015, 92, 356 – 372.

Org-Syn
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11. “Development of New P-Chiral P,π-Dihydrobenzooxaphosphole Hybrid Ligands for  Asymmetric Catalysis.”
Sieber, J. D.; Chennamadhavuni, D.; Fandrick, K. R.; Qu, B.; Han, Z. S.; Savoie, J.; Ma, S.; Samankumara, L. P.; Grinberg, N.; Lee, H.; Song, J. J.; Senanayake, C. H. Org. Lett. 2014, 16, 5494 – 5497.

JoshPhos-OL-2014
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10. “Design and Synthesis of Chiral Oxathiazinone Scaffolds:  Efficient Synthesis of Hindered Enantiopure Sulfinamides and Sulfinyl Ketimines.”
Han, Z. S.; Herbage, M. A.; Manganuru, H. P. R.; Xu, Y.; Zhang, L.; Reeves, J. T.; Sieber, J. D.; Li, Z.; Decroos, P.; Zhang, Y.; Li, G.; Li, N.; Ma, S.; Grinberg, N.; Wang, X.; Goyal, N.; Krishnamurthy, D.; Lu, B.; Song, J. J.; Wang, G.; Senanayake, C. H.  Angew. Chem. Int. Ed. 2013, 52, 6713 – 6717.

Sulfinamide-ACIE-2013
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9. “Efficient Asymmetric Synthesis of P-Chiral Phosphine Oxides via Properly Designed and Activated Benzoxazaphosphinine-2-oxide Agents.”
Han, Z. S.; Goyal, N.; Herbage, M. A.; Sieber, J. D.; Qu, B.; Xu, Y.; Li, Z.; Reeves, J. T.; Desrosiers, N. –D.; Ma, S.; Grinberg, N.; Lee, H.; Mangunuru, G. P. R.; Zhang, Y.; Krishnamurthy, D.; Lu, B. Z.; Song, J. J.; Wang, G.; Senanayake, C. H.  J. Am. Chem. Soc. 2013, 135, 2474 – 2477.

P-ChiralPhosphines-JACS-2013.gif
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Graduate and Postdoctoral:

8. “The Palladium Catalyzed Asymmetric Addition of Oxindoles and Allenes:  an Atom-Economical Versatile Method for the Construction of Chiral Indole Alkaloids.”
Trost, B. M.; Xie, J.; Sieber, J. D.  J. Am. Chem. Soc. 2011, 133, 20611 – 20622.

JACS-2011
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7. “Catalytic Enantioselective Conjugate Allylation of Unsaturated Methylidene Ketones.”
Brozek, L. A.; Sieber, J. D.; Morken, J. P. Org. Lett. 2011, 13, 995 – 997.

ConjugateAllyl-OL-2011
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6. “Catalytic Asymmetric Allylic Alkylation Employing Heteroatom Nucleophiles:  A Powerful Method for C-X Bond Formation.”
Trost, B. M.; Zhang, T.; Sieber, J. D.  Chem. Sci. 2010, 1, 427 – 440.

ChemSci-review
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5. “Asymmetric Total Synthesis of Soraphen A:  A Flexible Alkyne Strategy.”
Trost, B. M.; Sieber, J. D.; Qian, W.; Dhawan, R.; Ball, Z. T.  Angew. Chem. Int. Ed. 2009, 48, 5478 – 5481; Angew. Chem. 2009, 121, 5586 – 5589.

SoraphenA
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4. “Ni-Catalyzed Asymmetric Conjugate Allylation of Activated Enones.”
Sieber, J. D.; Morken, J. P.  J. Am. Chem. Soc. 2008, 130, 4978 – 4983.

JACS-article-2008
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3. “Catalytic Conjugate Addition of Allyl Groups to Styryl-Activated Enones.”
Sieber, J. D.; Liu, S.; Morken, J. P.  J. Am. Chem. Soc. 2007, 129, 2214 – 2213.

ConjuageAllyl-communication-JACS-2007
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2. “Sequential Pd-Catalyzed Asymmetric Allene Dibroation/α-Aminoallylation.”
Sieber, J. D.; Morken, J. P.  J. Am. Chem. Soc. 2006, 128, 74 – 75.

aminoallylation-JACS-2006
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1. “Palladium-Catalyzed Enantioselective Dibroation of Prochiral Allenes”Pelz, N. F.; Woodward, A. R.; Burks, H. E.; Sieber, J. D.; Morken, J. P.  J. Am. Chem. Soc. 2004, 126, 16328 – 16329.

Diboration-JACS
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Patents:

2. “Novel Chiral Dihydrobenzooxaphosphole Ligands and Synthesis Thereof.”
Desrosiers, J. –N.; Fandrick, D. R.; Haddad, N.; Li, G.; Patel, N. D.; Qu, B.; Rodriguez, S.; Senanayake, C. H.; Sieber, J. D.; Tan, Z.; Wang, X. –J.; Yee, N. K.; Li, Z.; Zhang, Y. U.S. Patent # 20180155375 A1 issued 06/07/2018.

1. “Novel Chiral Dihydrobenzoazaphosphole Ligands and Synthesis Thereof.”
Biswas, S.; Desrosiers, J. –N.; Lao, K.; Mangunuru, H. P. R.; Qu, B.; Rodriguez, S.; Senanayake, C. H.; Sieber, J. D.; Wang, X. –J.; Yee, N. K.; Zhang, Y. U.S. Patent # 20180155377 A1 issued 06/07/2018.

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